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Case Report
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| Metronidazole induced acute pancreatitis |
| Haroon Yousaf1, 2, Irfan Saddique3 |
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1Theda Clark Hospital, Neenah, WI, USA.
2Interfaith Medical Center, Brooklyn, New York, USA. 3Shifa College of Medicine, Islamabad, Pakistan. |
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doi:10.5348/ijcri-2012-04-114-CR-11
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Address correspondence to: Haroon Yousaf Theda Clark Hospital, 130 2nd Street Neenah WI, 54956 USA Phone: 920-729-3100 Email: drhy@hotmail.com |
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| How to cite this article: |
| Yousaf H, Saddique I. Metronidazole induced acute pancreatitis. International Journal of Case Reports and Images 2012;3(4):41–44. |
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Abstract
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Introduction:
Pancreatitis is a very rare adverse effect of metronidazole with only eight cases of metronidazole-induced pancreatitis reported so far.
Case Report: A 23-year-old African-American female developed acute pancreatitis following treatment with metronidazole for vaginal trichomoniasis. She took metronidazole at two different times and experienced the severe epigastric pain and vomiting one hour after each dose. These episodes were unrelated to alcohol ingestion, gallbladder disease or other known causes of pancreatitis. Laboratory studies revealed elevated amylase and lipase concentrations and CT scan confirmed the findings consistent with acute pancreatitis. After discontinuation of metronidazole, the patient's abdominal pain improved, and both amylase and lipase concentrations immediately declined and were within normal limits after one day. Conclusion: High degree of suspicion is warranted on the part of physicians to diagnose metronidazole induced pancreatitis in patients presenting with gastrointestinal symptoms after metronidazole exposure. We suggest that metronidazole be discontinued when clinical or biochemical features of acute pancreatitis occur, once other known causes of pancreatitis have been excluded and rechallenge should be avoided. | |
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Key Words:
Pancreatitis, Metronidazole, Drug toxicity
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Author Contributions:
Haroon Yousaf - Substantial contributions to conception and design, acquisition of data, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published Irfan Saddique - Substantial contributions to conception and design, analysis and interpretation of data, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission:
The corresponding author is the guarantor of submission. |
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Source of support:
None |
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Conflict of interest:
Authors declare no conflict of interest. |
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Copyright:
© Haroon Yousaf et. al. 2012; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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