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Case Report
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| Spontaneous morphological and cytogenetic remission of MDS: A case report and review of the literature |
| Mohamed Ifraz Hamid, Rebecca Maddams, |
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doi:10.5348/ijcri-2012-01-81-CR-3 |
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Address correspondence to: Mohamed Ifraz Hamid Email: ifrazh@yahoo.com |
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| How to cite this article: |
| Hamid MI, Maddams R. Spontaneous morphological and cytogenetic remission of MDS: A case report and review of the literature. International Journal of Case Reports and Images 2012;3(1):9-11. |
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Abstract
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Introduction:
Myelodysplastic syndromes (MDS) are a group of haemopoietic stem cell disorders characterised by cytopenias and dysplasia in one or more myeloid cell lines with a risk of developing acute leukaemia. MDS can occur as a primary event or following exposure to chemotherapy or radiotherapy. Spontaneous remission can occur but is rare.
Case Report: In this case report, a 39-year-old female developed MDS with a cytogenetic abnormality t (1;7) during treatment with cyclophosphamide for Wegener's granulomatosis. A spontaneous morphological and cytogenetic remission occurred six years after initial diagnosis. Conclusion: Case reports of spontaneous remission in patients with primary MDS occasionally appear in the literature however there are very few reports concerning remission of therapy related MDS. This case is unusual as the patient achieved complete haematological and cytogenetic remission of treatment related MDS on a reduction of cyclophosphamide. | |
| Key Words: Myelodysplastic syndromes, Haemopoietic stem, Acute leukaemia, MDS | |
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Author Contributions:
Mohamed Ifraz Hamid - Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Rebecca Maddams - Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission:
The corresponding author is the guarantor of submission. |
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Source of support:
None |
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Conflict of interest:
The authors declare no conflict of interest. |
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Copyright:
© Mohamed Ifraz Hamid et al. 2012; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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