| Table of Contents |  |
|
CASE REPORT
|
| Relationship between classical Hodgkin's lymphoma and diffuse large B-cell lymphoma: Separate entity or biologic continuum |
| Salvia Jain1, Bruce Raphael2, Kent P Friedman3, Xiaowei Chen, Sherif Ibrahim4, |
|
1Division of Hematology and Medical Oncology, NYU Cancer Institute, New York, NY, USA
2Division of Radiology, NYU Langone Medical Center, New York, NY, USA 3Division of Pathology, Columbia University Medical Center, New York, NY, USA 4Division of Hematopathology, NYU Cancer Institute, New York, NY, USA. |
|
doi:10.5348/ijcri-2011-05-33-CR-3
|
|
Address correspondence to: Dr. Salvia Jain NYU Langone Medical Center 550 First Avenue New York USA-10016 Phone: 001-650-224-0183 Fax: 001-212-562-1117 Email: salvia.jain@nyumc.org |
|
[HTML Full Text]
[PDF Full Text]
|
| How to cite this article: |
| Jain S, Raphael B, Friedman KP, Chen X, Ibrahim S. Relationship between classical Hodgkin's lymphoma and diffuse large B-cell lymphoma: Separate entity or biologic continuum. International Journal of Case Reports and Images 2011;2(5):13-20. |
|
Abstract
|
|
Introduction:
Cases of patients with non-Hodgkin's lymphoma observed after therapy for Hodgkin lymphoma have been reported. However, occurrence of non-Hodgkin's lymphomas in such settings at a previously uninvolved site is extremely rare. The mechanism behind this remains obscure thereby presenting diagnostic and therapeutic dilemma for the treating physician.
Case Report: We report a case of a 62-year-old woman who developed a large B-cell non-Hodgkin's lymphoma at a different anatomic site six months after receiving high dose chemotherapy and autologous stem cell transplantation for her relapsed Hodgkin lymphoma. We treated her with conventional combination chemoimmunotherapy following which she achieved durable complete remission. Conclusion: This case highlights the intriguing relationship between classical Hodgkin lymphoma and B-cell non-Hodgkin's lymphoma with respect to pathogenesis and its impact on therapeutic decisions and outcomes in such contentious cases which a clinician must face. | |
|
Key Words:
Classical Hodgkin lymphoma, Large B-cell lymphoma, Chemoimmunotherapy, B-cell gene rearrangement
| |
| [HTML Full Text] [PDF Full Text] |
|
Author Contributions:
Salvia Jain - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Bruce Raphael - Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Kent Friedman - Group 1 - Conception and design, Acquisition of data, Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published Xiaowei Chen - Group 1 - Conception and design, Acquisition of data, Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published Sherif Ibrahim - Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published |
|
Guarantor of submission:
The corresponding author is the guarantor of submission. |
|
Source of support:
None |
|
Conflict of interest:
The authors declare no conflict of interest with an institution or product mentioned in the manuscript. |
|
Copyright:
© Salvia Jain et al. 2011; This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see copyright policy for more information.) |
|
|