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CASE REPORT
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| Coexistent systemic amyloidosis, multiple myeloma, and refractory anemia with ringed sideroblasts in a previously untreated patient |
| Sangeeta Mehendale1, Pritesh Patel2, Valerie Lindgren1, Damiano Rondelli2, Sujata Gaitonde1 |
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1Department of Pathology, University of Illinois, Chicago, USA. 2Department of Medicine, University of Illinois, Chicago, USA. |
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doi:10.5348/ijcri-2011-02-17-CR-1
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Address correspondence to:
Sujata Gaitonde University of Illinois at Chicago College of Medicine Department of Pathology (MC 847) 840 South Wood Street; Room 110 CSN Chicago, IL 60612; USA Ph: 312 996 4206 Fax: 312 413 0156 E-mail: sgaitond@uic.edu |
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| How to cite this article: |
| Mehendale S, Patel P, Lindgren V, Rondelli D, Gaitonde S. Coexistent systemic amyloidosis, multiple myeloma, and refractory anemia with ringed sideroblasts in a previously untreated patient. International Journal of Case Reports and Images 2011;2(2):1-4. |
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Abstract
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Introduction:We report the first case of coexistent systemic amyloidosis, plasma cell myeloma (MM), and myelodysplastic syndrome (refractory anemia with ringed sideroblasts:MDS-RARS). Case Report: Our patient was diagnosed with amyloidosis of the liver, stomach and tongue following which a bone marrow biopsy was performed. Review of the bone marrow biopsy revealed the presence of two distinct entities that have rarely been detected together; MM and MDS-RARS. There was no history of prior radiation or chemotherapy. Conclusion: Concurrent de novo disease processes involving both myeloid and lymphoid cell lines may not be as rare as they seem. Cytopenias in patients with MM must trigger a thorough investigation for an associated concurrent myeloid disorder. Presence of concurrent MDS would influence the choice of therapy and these patients need to be watched closely for progression of the myeloid disorder. | |
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Key Words:
Myeloma, Myelodysplastic syndrome, De novo
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Author Contributions:
Sangeeta Mehendale - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Pritesh Patel - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Valerie Lindgren - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Damiano Rondelli - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Sujata Gaitonde - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published |
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Guarantor of submission:
The corresponding author is the guarantor of submission. |
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Source of support:
None |
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Conflict of interest:
The author(s) declare no conflict of interests. |
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Copyright:
© Sujata Gaitonde et. al. 2011; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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