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REVIEW ARTICLE
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| Tissue Microarray: A powerful and rapidly evolving tool for high-throughput analysis of clinical specimens |
| Anubha Singh1, Apurba Kumar Sau2 |
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1Research Associate, Division of Radiation Biology, Institute of Nuclear Medicine and Allied sciences, Delhi - 110054, India.
2Staff Scientist, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India. |
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doi:10.5348/ijcri-2010-09-1-RA-1
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Address correspondence to: Anubha Singh Research Associate Division of Radiation Biology Institute of Nuclear Medicine and Allied sciences Delhi - 110054 India. |
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| How to cite this article: |
| Singh A, Sau AK. Tissue Microarray: A powerful and rapidly evolving tool for high-throughput analysis of clinical specimens. IJCRI 2010;1(1):1-6. |
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Abstract
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This review discusses the various aspects of the Tissue microarray (TMA) technology and its applications in modern molecular and clinical research. Tissue microarrays (TMAs) allow a rapid, cost-effective, high through-put analysis of thousands of molecular markers at nucleic acids or protein level. This high through-put technology enables identification of diagnostic and prognostic markers, in an array of clinical tissue specimens and further translates molecular research to clinical research. A very notable advantage of tissue microarray technology is that it quantitatively amplifies the tissues available for testing, which are normally a limited source in the pathology labs. Various types of tumors, at various stages of disease progression can also be studied at a single platform, in identical conditions in less labor-intensive and cost-effective ways. The current perspectives of this technology in biomedical sciences are promising and researchers can benefit from the enormous data acquired through the use of TMA.
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Key Words:
Tissue microarray, Tumors, Immunohistochemistry, Quality control
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Author Contributions: Anubha Singh - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published; Apurba Kumar Sau - Conception and design, Drafting the article, Critical revision of the article, Final approval of the version to be published |
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Guarantor of submission:
The corresponding author is the guarantor of submission. |
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Source of support:
None |
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Conflict of interest:
The author(s) declare no conflict of interests |
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Copyright:
© Anubha Singh et al. 2010; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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