Case Report
 
An unusual presentation of odontogenic keratocyst with malignant changes in a 13-year-old girl
Manal Ibrahim Elnouaem1, Zeinab El Sayed Darwish2, Rana Aly Sharaf3
1Professor Oral Pathology, Phd, Professor, Oral Pathology Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
2Professor Oral Pathology, Phd, Oral Pathology Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
3Demonstrator, Oral medicine and Diagnosis, Demonstrator, Oral medicine and diagnosis Department, Faculty of Dentistry, Alexandria, University, Alexandria, Egypt.

Article ID: Z01201610CR10704ME
doi:10.5348/ijcri-2016116-CR-10704

Address correspondence to:
Dr. Manal Ibrahim Elnouaem
20 Mohamed Said Pasha Street
off Abdel Hamid El Deeb – Tharwat –Apt 601
Alexandria
Egypt, 21411

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How to cite this article
Elnouaem MI, El Sayed Darwish Z, Aly Sharaf R. An unusual presentation of odontogenic keratocyst with malignant changes in a 13-year-old girl. Int J Case Rep Images 2016;7(10):657–661.


Abstract
Introduction: Odontogenic keratocysts as defined by WHO are known for their characteristic behavior, high tendency to recur, unusual pattern of growth and different treatment methods. Squamous cell carcinoma on top of keratocysts is extremely rare and is mostly limited to jaw bones.
Case Report: We hereby report, not previously reported a characteristic case of an odontogenic keratocyst related to the anterior maxillary teeth in a teenage female of 13 years. On histological examination of the biopsy, frank invasion was seen and a diagnosis of squamous cell carcinoma on top of keratocyst was given.
Conclusion: The diagnosis was predicted on recognition of the histopathologic features of odontogenic keratocyst associated with dysplastic features of the epithelial lining and areas of invasion in other parts; the clinical symptoms are modest, only presenting a palatal swelling.

Keywords: Children population, Jaw bones, Odontogenic keratocyst, Squamous cell carcinoma


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Author Contributions
Manal Ibrahim Elnouaem – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting of the article, Revising it critically for important intellectual content, Final approval of the version to be published
Zeinab El Sayed Darwish – Acquisition of data, Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Rana Aly Sharaf – Acquisition of data, interpretation of data, Drafting of the article, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2016 Manal Ibrahim Elnouaem et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



About The Authors

Manal Ibrahim Elnouaem is Professor at Oral Pathology Department, Faculty of Dentistry, Alexandria University, Egypt. She earned Bachelor degree of oral medicine and surgery from Faculty of Dentistry, Alexandria University, Egypt and Masters and Phd degrees form Faculty of Dentistry, Alexandria University, Egypt. She has published 19 research papers in national and international academic journals. Her area of interests include squamous cell carcinoma, salivary gland tumors and odontogenic tumors and cysts.



Zeinab ELSayed Darwish is Head of Oral Pathology Department at University of Alexandria, Egypt. She earned Bachelor degree of oral medicine and surgery from Faculty of Dentistry, Alexandria University, Egypt and Masters and Phd degrees form Faculty of Dentistry, Alexandria University, Egypt. She has published 21 research papers in national and international academic journals. Her research interests include oral premalignant and malignant lesions, dermatologic diseases, bone diseases and tobacco effect on oral tissues.



Rana Aly Sharaf is Demonstrator at Oral Diagnosis and Oral Medicine Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt. She earned Bachelor Degree of oral medicine and surgery from Faculty of Dentistry, Alexandria University, Egypt. She intends to pursue a Masters Degree in Oral and Maxillofacial Radiology in future.