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Case Report
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| A rare presentation of calciphylaxis in normal renal function | ||||||
| Parin Rimtepathip1, David Cohen2 | ||||||
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1MS III, Mercer University School of Medicine.
2MD, Dermatologic Surgery Specialists, Macon, Georgia. | ||||||
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| How to cite this article |
| Rimtepathip P, Cohen D. A rare presentation of calciphylaxis in normal renal function. Int J Case Rep Images 2015;6(6):366–369. |
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Abstract
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Introduction:
Calciphylaxis is a rare and life- threatening condition in which extensive microvascular calcification in arterioles and occlusion of vessels lead to painful non-healing ulcers with high mortality rate. Calciphylaxis is mainly associated with end stage renal disease or hyperparathyroidism, with rare cases reported in cirrhosis patient.
Case Report: A 55-year-old Caucasian male with significant history of porphyria cutanea tarda and Hepatitis C complicated by cirrhosis with normal renal function presents with history of non-healing ulcers on both of his hands. The diagnosis of calciphylaxis was made by X-ray. Due to rapid progression of the ulcers to tissue necrosis and gangrene with no definite underlying pathology, the patient's hands were eventually amputated due to the inability to withstand pain. Conclusion: Patients presenting with painful ulceration of their fingers with history of cirrhosis and normal renal function should be worked up for calciphylaxis as part of the differential diagnosis, especially with low serum albumin level. Site of calciphylaxis also matters as there is a great difference between mortality rates of proximal versus distal. We postulate the idea of pathophysiological mechanism with further research needed. This case report should alert physicians that calciphylaxis does occurred in patients with cirrhosis and normal renal function. | |
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Keywords:
Calciphylaxis, Cirrhosis, Porphyria Cutanea Tarda, Hepatitis C
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Author Contributions
Parin Rimtepathip – Substantial contributions to conception and design, Drafting the article, Final approval of the version to be published David Cohen – Substantial contributions to conception and design, Drafting the article, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2015 Parin Rimtepathip et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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