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Case Report
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| Caspofungin may effective for initial treatment of pulmonary aspergillosis | ||||||
| Alper Sener1, Senol Kobak2, Timucin Alar3, Ugur Gonlugur4, Asli Muratli5 | ||||||
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1Onsekiz Mart University Faculty of Medicine, Infectious Disesae Department Terzioglu campus Canakkale/ Turkey.
2Onsekiz Mart University Faculty of Medicine, Rheumatology and Immunology Department Terzioglu campus Canakkale/Turkey. 3Onsekiz Mart University Faculty of Medicine, Thorasic Surgery Department Terzioglu campus Canakkale/Turkey. 4Onsekiz Mart University Faculty of Medicine, Pulmonary Disease Department Terzioglu campus Canakkale/Turkey. 5Onsekiz Mart University Faculty of Medicine, Pathology Department Terzioglu campus Canakkale/ Turkey. | ||||||
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| How to cite this article: |
| Sener A, Kobak S, Alar T, Gonlugur U, Muratli A. Caspofungin may effective for initial treatment of pulmonary aspergillosis. International Journal of Case Reports and Images 2013;4(3):161–164. |
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Abstract
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Introduction:
Invasive aspergillosis mostly involves lungs. Patients may present with fever, cough, hemoptysis and many other sign and symptoms. Underlying conditions that compromises pulmonary and immune responses to inhaled Aspergillus species serve as risk factors for pulmonary invasive aspergillosis. We are presenting a case of simple aspergilloma, successfully treated by caspofungin and surgery.
Case Report: A 64-year-old male patient has rheumatoid arthritis for ten years. Since three months he had interstitial pulmonary disease secondary to rheumatoid arthritis and hemoptysis. We performed microbiologic and pathologic investigations of the brochoalveolar lavage after computerized tomography for diagnosis of aspergillosis. Caspofungin was used for initial treatment of simple aspergilloma and also for follow-up treatment after apical wedge resection. The patient was discharged from the hospital at eighth week on itraconazol antifungal therapy. Conclusion: Three classes of drugs are available for the treatment of aspergillosis: polyens, azoles and echinocandins. Echinocandins have activity against Aspergillus spp. but have a limited role because they have not been studied for initial treatment of invasive aspergillosis. | |
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Keywords:
Antifungal treatment, Aspergillosis, Caspofungin
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Author Contributions
Alper Sener – Substantial contributions to conception and design, Acquisition of data, analysis and interpretation of data, Drafting the article, revising it critically for important intellectual content, and Final approval of the version to be published Senol Kobak – Substantial contributions to conception and design, Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published Timucin Alar – Substantial contributions to conception and design, Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published Ugur Gonlugur – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Asli Muratli – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© Alper Sener et al. 2013; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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