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Case Report
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| Selenium adjuvant therapy in central nervous system infection | ||||||
| Ladislav Kočan1, Janka Vaŝková2, Jozef Firment3, Ladislav Vaŝko4 | ||||||
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1Anaesthetist, 1st Clinic of Anaesthesiology and Intensive Medicine, Louis Pasteur University Hospital, Košice, Slovak Republic.
2Research Assistant Professor, Deptartment of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Košice, Slovak Republic. 3Head of 1st Clinic of Anaesthesiology and Intensive Medicine, Faculty of Medicine, Pavol Jozef Šafárik University in Košice and Louis Pasteur University Hospital, Košice, Slovak Republic. 4Associate Professor, Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Košice, Slovak Republic. | ||||||
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| How to cite this article: |
| Kocan L, Vaŝková J, Firment J, Vaŝko L. Selenium adjuvant therapy in central nervous system infection. International Journal of Case Reports and Images 2012;3(11):50–55. |
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Abstract
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Introduction:
Bacterial meningitis is associated with permanent after effects resulting from damage to central nervous system structures in affected patients. Massive release of inflammatory mediators and production of reactive oxygen species often complicate the course of the disease and result in the development of sepsis and worsening of the patient's prognosis.
Case Report: A 38-year-old male patient of Slovak origin with bacterial meningitis and serious sepsis was admitted to an intensive care unit. During a six-day supplementation of selenite pentahydrate at a dose of 750 µg per day, increased activity of the antioxidant enzyme glutathione peroxidase was recorded, the co-factor of which is selenium and synergistically acting enzyme glutathione reductase, respectively. A concurrent slight decrease in the activity of superoxide dismutase and the reduced levels of inflammatory markers indicated the development of an adequate response of the body to the production of free radicals and their elimination. Conclusion: It has been demonstrated that supplementation of critically ill patients with selenium can improve their antioxidant status and may also decrease oxidation damage to neurons and glial cells. Selenium as an adjuvant showed potential efficacy in reducing complications and improving patients' outcomes in the case of lowered antioxidant status during bacterial meningitis, firstly as a pro-oxidant to aid the elimination of microbial pathogens, and secondly as the antioxidant selenoenzymes. The results obtained allowed us to conclude that this can be a suitable complementary intervention in patients with pneumococcal meningitis and developing sepsis. | |
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Key Words:
Meningitis, Sepsis, Selenium, Selenoenzyme
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Author Contributions:
Ladislav Kočan – Substancial conctribution to conception and design, Acquisition of data, Drafting the article, Final approval of the version to be published Janka Vaŝková – Substancial conctribution to conception and design, Analysis and interpretation of data, Drafting the article, Final approval of the version to be published Jozef Firment – Substancial conctribution to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published Ladislav Vaŝko – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission:
The corresponding author is the guarantor of submission. |
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Source of support:
None |
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Conflict of interest:
Authors declare no conflict of interest. |
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Copyright:
© Ladislav Kocan et al. 2012; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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