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Case Report
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| Congenital nephrogenic diabetes insipidus presenting after acute pyelonephritis | ||||||
| Christian Castillo1, Poonam Bherwani2, Evelyn Erickson3, Gerard Prosper4 | ||||||
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1Neonatology Fellow, Cook County Hospital, Chicago, Illinois, USA.
2Department of Pediatrics, Lincoln Medical and Mental Health Center, Bronx, New York, USA. 3Research Assistant, Department of Pediatrics, Lincoln Medical and Mental Health Center, Bronx, New York, USA. 4Attending of Pediatric Nephrology, Lincoln Medical and Mental Health Center, Bronx, New York, USA. | ||||||
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| How to cite this article: |
| Castillo C, Bherwani P, Erickson E, Prosper G. Congenital nephrogenic diabetes insipidus presenting after acute pyelonephritis. International Journal of Case Reports and Images 2012;3(11):25–27. |
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Abstract
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Introduction:
Diabetes insipidus (DI) is characterized by the inability to concentrate urine. While central DI is caused by failure to release enough functional vasopressin, nephrogenic DI (NDI) is due to the insensitivity of the distal nephron to the effect of antidiuretic hormone (ADH).
Case Report: A 5-day-old newborn male was admitted for isolated fever and a questionable early right upper lobe infiltrate. He gradually developed hypernatremia and increased osmolality. As part of his work up for fever, he had a urine culture of 30K colonies of Enterococcus faecalis. His vasopressin test was negative. Conclusion: The polyuria and polydipsia associated with genetic NDI usually presents within the first several weeks of life but may only become apparent after weaning or with longer periods of nighttime fasting. The acute pyelonephritis of this newborn may have been the initial trigger for the congenital NDI. Accurate diagnosis of this patient helped to also diagnose his maternal uncle and provide clues to the current condition of his maternal grandmother. Early diagnosis and management can prevent the development of neurological and developmental complications associated with NDI. | |
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Key Words:
Congenital Diabetes Insipidus, Nephrogenic Diabetes Insipidus, Acute Pyelonephritis
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Author Contributions:
Christian Castillo - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Poonam Bherwani - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Evelyn Erickson - Acquisition of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Gerard Prosper - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published |
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Guarantor of submission:
The corresponding author is the guarantor of submission. |
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Source of support:
None |
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Conflict of interest:
Authors declare no conflict of interest. |
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Copyright:
© Christian Castillo et al. 2012; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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