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Case Report
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| Octreotide induced thrombocytopenia | ||||||
| Haroon Yousaf1, Irfan Saddique2 | ||||||
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1Theda Clark Hospital, Neenah, WI, USA.
2Interfaith Medical Center, Brooklyn, New York, USA. | ||||||
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| How to cite this article: |
| Yousaf H, Saddique I. Octreotide induced thrombocytopenia. International Journal of Case Reports and Images 2012;3(11):14–16. |
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Abstract
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Introduction:
Thrombocytopenia due to octreotide is a rare but known phenomenon. Only three cases of octreotide induced thrombocytopenia have been reported so far.
Case Report: Here we report a case of a 76-year-old diabetic male who was brought to the emergency room after being found unconscious. In the ER, his blood glucose level was 43 mg/dL. He was taking glyburide 5 mg by mouth daily prior to admission. Escalated dextrose infusion with repeated doses of D50W failed to sustain his blood glucose, which remained in the range of 30 to 50 mg/dL. Salvage treatment with intravenous octreotide was implemented successfully; only one dose of D50W was required after octreotide initiation and blood glucose normalized within several hours. However, a significant drop in patient's platelet count was noted after initiation of octreotide therapy, that persisted until the drug was discontinued. Rapid recovery was observed after discontinuation of octreotide. Conclusion: High degree of suspicion is warranted on the part of physicians to suspect octreotide as a causative factor for thrombocytopenia. We suggest that octreotide be discontinued when thrombocytopenia occur, once other known causes of thrombocytopenia have been excluded. | |
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Key Words:
Octreotide, Thrombocytopenia, Drug toxicity
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Author Contributions:
Haroon Yousaf – Substantial contributions to conception and design, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Irfan Saddique – Substantial contributions to conception and design, Analysis and interpretation of data, Drafting the article, Final approval of the version to be published |
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Guarantor of submission:
The corresponding author is the guarantor of submission. |
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Source of support:
None |
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Conflict of interest:
Authors declare no conflict of interest. |
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Copyright:
© Haroon Yousaf et al. 2012; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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