Review Article
 
Schwannomas of Gastrointestinal Tract; a comprehensive review
Heng Siang Ting1, BM Yashodhara2, Htoo Htoo Kyaw Soe3, Uduman Ali Mohamed Yousuf4, Jaswant Singh5
1Senior Medical Officer, Department of Surgery, Hospital Sebarang Jaya, Penang, Malaysia
2Professor, Department of Medicine, Melaka Manipal Medical College, Melaka, Malaysia
3Associate Professor, Department of Community Medicine, Melaka Manipal Medical College, Melaka, Malaysia
4Professor & HOD, Department of Medicine, Melaka Manipal Medical College, Melaka, Malaysia
5Clinical Professor, Department of Medicine, Melaka Manipal Medical College, Melaka, Malaysia

Article ID: 100945Z01HT2018
doi: 10.5348/100945Z01HT2018RA

Corresponding Author:
Prof. Dr. BM Yashodhara
Department of General/Internal Medicine
Melaka Manipal Medical College
MAHE, Jalan Batu Hampar, Bukit Baru, Melaka, Malaysia, 75150

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How to cite this article
Ting HS, Yashodhara BM, Soe HHK, Yousuf UAM, Singh J. Schwannomas of Gastrointestinal Tract; a comprehensive review. Int J Case Rep Images 2018;9:100945Z01HT2018.


ABSTRACT

Gastrointestinal Schwannomas (GIS) are neurogenic, spindle cell, mesenchymal tumors, and arise from Schwann cells of myenteric plexus; the cells which form the sheath of the nerves. Schwannomas (SNs) usually arise from spinal roots and peripheral nerves in Schwannomatosis, the third major form of neurofibromatosis, but they are most well-known to originate from cranial nerves as in vestibular schwannomas. On the contrary, a sporadic Schwannoma which occurs in hollow organs such as the GI tract is remarkably rare. The Gastrointestinal Schwannomas pose a diagnostic & interventional challenge as it is difficult to differentiate them, peri-operatively or pre-operatively, from more commonly occurring, more malignant, Gastrointestinal-Stromal Tumors (GIST). The exact incidence of gastrointestinal Schwannomas is not known, due to lack of consensus in the nomenclature of these tumors; they are called schwannomas, neurinomas, neurilemmomas, neurolemmomas, and Schwann cell tumors. The literature review suggests that they contribute to 1% gastrointestinal tumors and 2–8% of gastrointestinal mesenchymal tumors.

Keywords: Comprehensive review, Gastrointestinal schwannomas, Gastrointestinal-Stromal tumors, Gastrointestinal tract, Schwannoma


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Acknowledgements
Melaka Manipal Medical College and MAHE
Author Contributions
Heng Siang Ting – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
BM Yashodhara – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Htoo Htoo Kyaw Soe – Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Uduman Ali Mohamed Yousuf – Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Jaswant Singh – Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of Submission
The corresponding author is the guarantor of submission.
Source of Support
None
Consent Statement
Written informed consent was obtained from the patient for publication of this study.
Conflict of Interest
Author declares no conflict of interest.
Copyright
© 2018 Heng Siang Ting et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.