Case Report
 
Primary biphasic synovial sarcoma of the lung: A case report
Hiroshi Hashimoto1, Yuichi Ozeki1, Koji Kameda1, Hideyuki Shimazaki2, Kuniaki Nakanishi2, Shinichi Taguchi1
1Department of Thoracic Surgery, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama, Japan
2Department of Pathology and Laboratory Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama, Japan

Article ID: 100938Z01HH2018
doi: 10.5348/100938Z01HH2018CR

Corresponding Author:
Hiroshi Hashimoto
Department of Thoracic Surgery
National Defense Medical College
3-2, Namiki, Tokorozawa, Saitama 359-8513, Japan

Access full text article on other devices

  Access PDF of article on other devices

[HTML Full Text]   [PDF Full Text] [Print This Article]
[Similar articles in PubMed] [Similar articles in Google Scholar]



How to cite this article
Hashimoto H, Ozeki Y, Kameda K, Shimazaki H, Nakanishi K, Taguchi S. Primary biphasic synovial sarcoma of the lung: A case report. Int J Case Rep Images 2018;9:100938Z01HH2018.


ABSTRACT

Introduction: Primary synovial sarcoma of the lung is an extremely rare tumor, accounting for less than 0.5% of all lung tumors. The diagnosis is established only after sarcoma-like primary lung malignancies and metastatic sarcoma have been excluded.

Case Report: A 70-year-old female patient was admitted to our hospital because of a right lower lobe lung mass. Computed tomography-guided needle biopsy revealed the presence of spindle cell sarcoma. The patient underwent right lower lobectomy and combined resection of the pericardium. Histologically, the tumor displayed tubular proliferation of epithelial cells and fascicular proliferation of spindle cells. Immunohistochemically, both tumor cell types were positive for vimentin and bcl-2. Pleomorphic carcinoma or synovial sarcoma was suggested as a diagnosis. We found the presence of SYT-SSX fusion gene transcripts in RNA samples from frozen tissue from the tumor. The final diagnosis was primary pulmonary biphasic synovial sarcoma.

Conclusion: We report an extremely rare case of primary pulmonary biphasic synovial sarcoma. Our findings indicate that molecular detection of SYT-SSX fusion gene transcripts is very helpful and may be necessary when synovial sarcoma is recognized at uncommon sites.

Keywords: Primary pulmonary synovial sarcoma, Synovial sarcoma, SYT-SSX fusion gene transcripts


[HTML Full Text]   [PDF Full Text]

Author Contributions
Hiroshi Hashimoto – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Yuichi Ozeki – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Koji Kameda – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Hideyuki Shimazaki – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Kuniaki Nakanishi – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Shinichi Taguchi – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of Submission
The corresponding author is the guarantor of submission.
Source of Support
None
Consent Statement
Written informed consent was obtained from the patient for publication of this case report.
Conflict of Interest
Author declares no conflict of interest.
Copyright
© 2018 Hiroshi Hashimoto et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.