Case Report
 
Primary pure squamous cell carcinoma of the stomach: Unique case in one institution
Ana Marta Pereira1, Joana Magalhães1, Rui Ferreira Almeida2, Artur Trovão Lima3, Albino Oliveira4, Mário Nora5
1Resident in the General Surgery Department, Centro Hospitalar Entre Douro e Vouga, Santa Maria da Feira, Portugal
2Hospital Assistant in the General Surgery Department and PhD student, Centro Hospitalar Entre Douro e Vouga, Santa Maria da Feira, Portugal
3Graduated Hospital Assistant in the General Surgery Department, Centro Hospitalar Entre Douro e Vouga, Santa Maria da Feira, Portugal
4Director of Pathology Department, Centro Hospitalar Entre Douro e Vouga, Santa Maria da Feira, Portugal
5Director of General Surgery Department, Centro Hospitalar Entre Douro e Vouga, Santa Maria da Feira, Portugal

Article ID: 100885Z01AP2018
doi:10.5348/100885Z01AP2018CR

Corresponding Author:
Ana Marta Pereira,
Centro Hospitalar Entre Douro e Vouga,
General Surgery Department (8th floor),
R. Dr. Cândido Pinho, 4520-211,
Santa Maria da Feira, Portugal

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How to cite this article
Pereira AM, Magalhães J, Almeida RF, Lima AT, Oliveira A, Nora M. Primary pure squamous cell carcinoma of the stomach: Unique case in one institution. Int J Case Rep Images 2018;9:100885Z01AP2018.


ABSTRACT

Introduction: Pure primary gastric squamous cell carcinoma is rare, accounting for 0.04–0.07% of all gastric cancers. The pathogenesis and behaviour are unclear and treatment strategy is controversial, and so, the prognosis is poor in almost all reported cases. The authors describe a rare case of long survival of the disease, and an unique case in an institution.
Case Report: A Caucasian woman was referred to our hospital by a tertiary centre with a non-healing, histologically inconclusive ulcer. Histologic examination of the biopsy taken during a repeated esophagogastroduodenoscopy revealed squamous cell carcinoma. The proposed treatment was total gastrectomy with D2 lymphadenectomy. Squamous cell tumor with no dysplasia or metaplasia was found in the specimen. Adjuvant chemotherapy was done with no relapse evident even 18 months follow-up.
Conclusion: Gastric squamous cell carcinomas are rare tumors with unpredictable behaviour. The absence of glandular cells, dysplasia or metaplasia suggests a heterotopic foci origin, as well the squamous nature of the only lymph node metastasis. The success of this case is probably related to the early diagnosis, radical surgery and systemic adjuvant therapy.

Keywords: Stomach, Squamous cell carcinoma, Tumor



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Acknowledgements
We would like to acknowledge the Anatomic Pathology Department of Centro Hospitalar Entre Douro e Vouga for the contribution in the diagnosis of this case and the availability to manage the figures; all the surgical esophagogastric team of General Surgery Department for the assistance in the management of this patient.

Author Contributions
Ana Marta Pereira – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Joana Magalhães – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Rui Ferreira Almeida – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Artur Trovão Lima – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Albino Oliveira – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Mário Nora – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of Submission
The corresponding author is the guarantor of submission.
Source of Support
None
Consent Statement
Written informed consent was obtained from the patient for publication of this case report.
Conflict of Interest
Author declares no conflict of interest.
Copyright
© 2018 Ana Marta Pereira et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.