Introduction: Obscure gastrointestinal bleeding (OGIB) represents about 5% of all gastrointestinal bleeds. This can pose a huge diagnostic challenge for clinicians. Small bowel angiodysplasia is a rare but important cause of OGIB that is difficult to diagnose and treat.
Case Report: We present a case of a 53-year-old female with a one-month history of melena and symptomatic anemia who presented to general hospitals in Yangon, Myanmar. After multiple investigations, she was diagnosed with jejunal angiodysplasia. We highlight the challenges that come with diagnosing and managing a rare but important cause of upper gastrointestinal bleeding, made even more difficult in a resource-limited setting where healthcare is not always affordable and accessible.
Conclusion: Small bowel angiodysplasia should be on the differential list for all patients who present with obscure gastrointestinal bleeding or any gastrointestinal bleeding. Early diagnosis is important so that appropriate treatment can be administered for this potentially life-threatening condition.

Keywords: Jejunal angiodysplasia, Obscure gastrointestinal bleeding