International Journal of Case Reports and Images - IJCRI - Case Reports, Case Series, Case in Images, Clinical Images

   
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Takayasu's arteritis: Rare but not infrequent...
Tasnim Ahsan1, Uzma Erum2, Rukhshanda Jabeen3, Danish Khowaja2, Urooj Lal Rehman3
1FRCP (Glasg), FRCP (Edin), FRCP(Lon), MRCP(Lon), Professor of Medicine, Medical Unit - II, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
2MBBS, Postgraduate Trainee (for FCPS - Medicine), Medical Unit - II, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
3MBBS, FCPS, Senior Registrar,Medical Unit - II, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

doi:10.5348/ijcri-201602-CS-10063

Address correspondence to:
Dr. Uzma Erum
Medical Unit - II, Jinnah Postgraduate Medical Centre
Rafiquee Shaheed Road
Karachi
Pakistan, 75510

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How to cite this article
Ahsan T, Erum U, Jabeen R, Khowaja D, Rehman UL. Takayasu's Arteritis: Rare but not infrequent...? Int J Case Rep Images 2016;7(2):75–80.


Abstract
Introduction: Takayasu's arteritis is a chronic systemic vasculitis, mainly involving aorta and its major branches. It presents clinically with varied ischemic symptoms, either due to stenotic lesions or thrombus formation.
Case Series: We report a series of five patients with the diagnosis of Takayasu's arteritis. Four of them were females and one was male. The range of clinical presentation included shortness of breath leading to congestive heart failure in two patients; loss of consciousness with hemiparesis due to stroke secondary to vasculitis in one patient; limb claudication and acute severe backache in the thoracolumbar region in the other two. Two patients, the one presenting with stroke and other presenting with limb claudication, were classified as Takayasu's type-I; Two of the patients with heart failure were labeled as Takayasu's type-II and III. The patient with thoracolumbar pain was diagnosed as Takayasu's type-IV. All patients were treated with steroid and/or azathioprine.
Conclusion: Although, considered to be a rare disease, Takayasu's arteritis is not infrequent, as we report five cases seen over a four year period. A high index of suspicion is required for early diagnosis, so as to reduce the significant morbidity associated with the disease.

Keywords: Azathioprine, Takayasu's arteritis, Vasculitis, Immunosuppression


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Author Contributions:
Tasnim Ahsan – Substantial contributions to the conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Uzma Erum – Substantial contributions to the conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Rukhshanda Jabeen – Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Danish Khowaja – Acquisition of data, Analysis and the interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Urooj Lal Rehman – Substantial contributions to the conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2016 Tasnim Ahsan et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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