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Case Report
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| Cryptococcus gattii meningitis in a young adult in South India: A case report | ||||||
| Alagiri Sivaranjini1, Sekar Uma2, Kindo Anupma Jyoti3, V. Shankar4 | ||||||
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1MBBS, Final year post graduate in MD Microbiology, Department of Microbiology, Sri Ramachandra Medical College & Research Institute, Chennai, India.
2Professor and Head, Department of Microbiology, Sri Ramachandra Medical College & Research Institute, Chennai, India. 3Professor, Department of Microbiolgy, Sri Ramachandra Medical College & Research Institute, Chennai, India. 4Professor of Neurology, Sri Ramachandra Medical College & Research Institute, Chennai, India. | ||||||
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| How to cite this article |
| Sivaranjini A, Uma S, Jyoti KA, Shankar V. Cryptococcus gattii meningitis in a young adult in South India: A case report. Int J Case Rep Images 2015;6(11):702–706. |
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Abstract
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Introduction:
Cryptococcus species is one of the leading causes of invasive fungal infections in the world today. The clinical differences between the two Cryptococcus species, namely, Cryptococcus neoformans and Cryptococcus gattii depends on the ecology, epidemiology, virulence of the strain and immune status of the host. Cryptococcus gattii is an environmental fungus of the tropics and subtropics but is now known to cause sporadic infections in non-endemic regions as well.
Case Report: This paper reports a case of cryptococcal meningoencephalitis in a young, immunocompetent male, in South India, which is deemed a non-endemic region for Cryptococcus gattii infections. The patient presented with sub acute symptoms of headache and visual disturbances of two months duration. Cerebrospinal fluid was sent for investigation. Diagnosis was done by demonstration of capsule by microscopy, culture, detection of capsular antigen by latex agglutination and further confirmed by gene sequencing. In spite of intensive therapy, the disease progressed rapidly and the patient succumbed to the infection. Conclusion: Cryptococcus gattii, which was reported as a fungal pathogen of the endemics, is no longer considered as an accidental pathogen. Prompt detection and timely intervention is of utmost importance in treating this serious infection. | |
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Keywords:
Cryptococcus gattii, Cryptococcus neoformans, Invasive fungal infections, Meningitis
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Author Contributions
Sivaranjini Alagiri – Acquisition of data, Analysis and interpretation of data, Drafting the article, Final approval of the version to be published Uma Sekar – Substantial contributions to conception and design, Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Anupma Jyoti Kindo – Substantial contributions to conception and design, Analysis of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published V. Shankar – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2015 Sivaranjini Alagiri et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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